SYSTEMS XCELLENCE TO HOST CONFERENCE CALL TO DISCUSS 2006 FIRST QUARTER RESULTS 

Results to be released Thursday, May 4th at 7:00am

MILTON, Ontario -April 27, 2006, Systems Xcellence Inc., (TSX: SXC) announces that it will hold a conference call to discuss its 2006 first quarter financial results. Mr. Gordon Glenn, President and Chief Executive Officer will host the call.

DATE: Thursday May 4, 2006
       
TIME: 8:30 am, Eastern Standard Time
        
DIAL IN NUMBER: 416-644-3429 or 1-800-814-4857
       
TAPED REPLAY: 416-640-1917 or 1-877-289-8525
Available until May 11, 2006
       
REFERENCE NUMBER: 21185972

      
WEBCAST: A live audio webcast of the call will be available at www.sxc.com and www.newswire.ca. Webcast attendees are welcome to listen to the conference in real-time or on-demand at your convenience. The webcast will be archived for 360 days.

Please connect to this website at least 15 minutes prior to the conference call to ensure adequate time for any software download that may be needed to hear the webcast.

About Systems Xcellence Inc.

Systems Xcellence (SXC) is headquartered in Milton, Ontario with offices and processing centres in Lombard, Illinois, Warminster, Pennsylvania, Scottsdale, Arizona and Victoria, British Columbia.  Through its subsidiary, SXC Health Solutions, Inc., SXC is a leading provider of healthcare information technology solutions and services to the U.S. healthcare benefits management industry. The company’s product offerings and solutions combine a wide range of software applications, application service provider (ASP) processing services and professional services, designed for many of the largest organizations in the pharmaceutical supply chain, such as pharmacy benefit managers, managed care organizations, independent, chain and mail-order pharmacies and other healthcare intermediaries. SXC can be found on the Internet at www.sxc.com. 

This press release contains forward-looking statements based on current expectations. These forward-looking statements entail various risks and uncertainties that could cause actual results to differ materially from those reflected in these forward-looking statements. Risks and uncertainties about the Company's business are more fully discussed in the Company's Annual Information Form.