Systems Xcellence HOSTS ANNUAL AND SPECIAL MEETING OF SHAREHOLDERS -
MAY 17, 2006 

MILTON, Ontario May 16, 2006, Systems Xcellence Inc., (“SXC”) (TSX: SXC) a leading provider of healthcare information technology solutions throughout the pharmaceutical supply chain, will be holding its Annual and Special Meeting of Shareholders on May 17th, 2006 at the TSX Conference Centre, Gallery Room, Toronto, Ontario. The meeting will begin at 4:30 p.m. EST. 

If you are unable to attend the meeting, a live audio version will be available on the Internet at www.sxc.com or www.newswire.ca. A replay of the Annual Meeting of Shareholders will also be archived at www.sxc.com for 365 days.  

About Systems Xcellence Inc.

Systems Xcellence (SXC) is headquartered in Milton, Ontario with offices and processing centres in Lombard, Illinois, Warminster, Pennsylvania, Scottsdale, Arizona and Victoria, British Columbia.  Through its subsidiary, SXC Health Solutions, Inc., SXC is a leading provider of healthcare information technology solutions and services to the U.S. healthcare benefits management industry. The company’s product offerings and solutions combine a wide range of software applications, application service provider (ASP) processing services and professional services, designed for many of the largest organizations in the pharmaceutical supply chain, such as pharmacy benefit managers, managed care organizations, independent, chain and mail-order pharmacies and other healthcare intermediaries. SXC can be found on the Internet at www.sxc.com. 

This press release contains forward-looking statements based on current expectations. These forward-looking statements entail various risks and uncertainties that could cause actual results to differ materially from those reflected in these forward-looking statements. Risks and uncertainties about the Company's business are more fully discussed in the Company's Annual Information Form.